Now it came to pass, when men began to multiply on the face of the earth, and daughters were born to them, that the sons of God saw the daughters of men, that they were beautiful; and they took wives for themselves of all whom they chose.

And the Lord said, “My Spirit shall not strive with man forever, for he is indeed flesh; yet his days shall be one hundred and twenty years.”

There were giants on the earth in those days, and also afterward, when the sons of God came in to the daughters of men and they bore children to them. Those were the mighty men who were of old, men of renown.

Genesis 6:1–4

Human creatures were not the only ones to understand the meaning and significance of God’s words in Genesis 3:15. Satan, to whom those words were addressed, also understood them. In Genesis 6:1–4 we see Satan’s first attempt to thwart God’s messianic program. Since Messiah is to be the Seed of the Woman, Satan’s objective must be to corrupt this line of descent.*

*Fruchtenbaum, Arnold G. Messianic Christology: A Study of Old Testament Prophecy Concerning the First Coming of the Messiah. Tustin, CA: Ariel Ministries, 1998.